Search on: MAP KINASE KINASE KINASES 
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Descriptor English:   MAP Kinase Kinase Kinases 
Descriptor Spanish:   Quinasas Quinasa Quinasa PAM 
Descriptor Portuguese:   MAP Quinase Quinase Quinases 
Synonyms English:   MAPK-ERK Kinase Kinases
MAPKKKs
MEK Kinases
MEKKs  
Tree Number:   D08.811.913.696.620.682.700.559
D12.644.360.400
D12.776.476.400
Definition English:   Mitogen-activated protein kinase kinase kinases (MAPKKKs) are serine-threonine protein kinases that initiate protein kinase signaling cascades. They phosphorylate MITOGEN-ACTIVATED PROTEIN KINASE KINASES; (MAPKKs) which in turn phosphorylate MITOGEN-ACTIVATED PROTEIN KINASES; (MAPKs). 
See Related English:   MAP Kinase Signaling System
 
History Note English:   2000; use MAP KINASE KINASE KINASE (1992-1999) 
Allowable Qualifiers English:  
AD administration & dosage AE adverse effects
AN analysis AI antagonists & inhibitors
BI biosynthesis BL blood
CF cerebrospinal fluid CS chemical synthesis
CH chemistry CL classification
CT contraindications DF deficiency
DU diagnostic use DE drug effects
EC economics GE genetics
HI history IM immunology
IP isolation & purification ME metabolism
PK pharmacokinetics PD pharmacology
PH physiology PO poisoning
RE radiation effects SE secretion
ST standards SD supply & distribution
TU therapeutic use TO toxicity
UL ultrastructure UR urine
Record Number:   34448 
Unique Identifier:   D020930 

Occurrence in VHL: 		 

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